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Verapamil

Summary

Persistence. It cannot be excluded that verapamil is persistent, due to the lack of data.
Bioaccumulation. Verapamil has low potential for bioaccumulation.
Toxicity. Verapamil has moderate acute toxicity.
Risk. Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.

 

The data on hazard and risk are based on previous environmental information on fass.se from 2013. Environmental information is missing (2022-05-18). It is voluntary for manufacturers to provide information about environmental impact on fass.se.

Detailed information

Fass environmental information

Fass environmental information for Isoptin (verapamil) from Abbott (downloaded 2013-06-25).

Hazard

Persistence: No data.

Bioaccumulation: Log Kow for veramapil hydrochloride is 3.79 which indicates a low potential for bioaccumulation. However, due to extensive metabolism, bioaccumulation is not assumed to occur.

Toxicity: There is data for one trophic levels, crustacean (Daphnia Magna) 54010 microg/L.

Risk

PEC/PNEC (μg / L) = 0.203/54.01 = 0.0038, but since data are based on one trophic level, we (the company ed. remark) have chosen the risk phrase" Available ecotoxicological data do not exclude risk of environmental impact.

Pharmaceuticals residues in the aquatic environment in Sweden

Verapamil is included in screening studies in Region Stockholm but has been below the detection limits in recent years. Verapamil has also been included in national screening programs.

References

  1. Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
  2. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3. Pharmaceuticals.
  3. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.

Author: Health and Medical Care Administration, Region Stockholm