Persistence. Warfarin is potentially persistent.
Bioaccumulation. Warfarin has low potential for bioaccumulation.
Toxicity. Warfarin has moderate acute toxicity.
Risk. The use of warfarin (sales data Sweden 2010) has been considered to result in insignificant environmental risk.
The data on hazard and risk are based on previous environmental information on fass.se. Environmental information is missing (2022-06-17). It is voluntary for manufacturers to provide information about environmental impact on fass.se.
Fass environmental information
Fass environmental information for Warfarin Orion from Orion Pharma (downloaded 2013-06-17).
Persistence: 0% degrades after 28 days (OECD 301D).
Bioaccumulation: Log Kow < 0 (OECD117).
Acute toxicity: There are data for 3 trophic levels, most sensitive algae (Pseudokirchneriella subcapitata) 11000 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2010. PEC/PNEC = 0.00315 which gives the risk insignificant.
Pharmaceuticals residues in the aquatic environment in Region Stockholm, Sweden
Warfarin has previously been found in purified wastewater in Region Stockholm (2005–2012). Warfarin is also included in the report Pharmaceutical residues in Stockholm's aquatic environment from 2010.
Author: Health and Medical Care Administration, Region Stockholm