Persistence. Zolmitriptan is degraded in the environment.
Bioaccumulation. Zolmitriptan has low potential for bioaccumulation.
Toxicity. Zolmitriptan has moderate chronic toxicity.
Risk. The use of zolmitriptan (sales data Sweden 2019) has been considered to result in insignificant environmental risk.
This summary information comes from Fass.
Fass environmental information
Fass environmental information for Zomig (zolmitriptan) from Grunenthal Sweden (downloaded 2023-02-06).
Persistence: "In this case, the total system half-life was not reported; however, as detailed above, the report shows that total amount of radioactivity, attributable to zolmitriptan in the water and sediment extract combined, is <50% after 14d in both the high- and low- organic carbon test systems. The Fass.se guidance indicates that the persistence criteria should be based on loss of parent material and therefore both water/sediment systems would fulfil the <32d DT50 criteria." See further the Fass text.
Bioaccumulation: Log D at PH 7 = -1.29.
Chronic toxicity: There are data for 3 trophic levels, most sensitive fish (Pimephales promelas) NOEC 1000 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 0.0000115 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm