The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and T are from Fass.se.
Levels of felodipine measured in the environment in Sweden are estimated to be high enough to give therapeutic levels in fish, based on the fat solubility. Mechanism based data is missing.
Felodipine is included in the Stockholm County Council's table of pharmaceuticals with risk for negative environmental impact according to the environmental programme 2017–2021. Felodipine has been detected in treated wastewater in Stockholm County at the beginning of the last five-year period (2012–2016).
Fass environmental information for Plendil (felodipine) (downloaded 2018-05-23).
Persistence: "Felodipine is not readily biodegradable." and is potentially persistent.
Bioaccumulation: Log P = 3.86.
Acute toxicity: There are data for 3 trophic levels, lowest for fish 0.05 mg/L.
PEC/PNEC is based on sales data in Sweden in 2014. PEC/PNEC = 0.74, which gives the risk low, i.e. consideration has not been given to measured levels in the environment.
Concrete proposals on how to work to reduce emissions of environmentally harmful pharmaceuticals on the list have been developed in close cooperation with the Stockholm Drug and Therapeutics Committee's expert advice. The action proposals were developed from an environmental perspective. The patient's best always goes first and several pharmaceuticals on the list are also included in the Wise list. However, for such pharmaceuticals, there may be measures that could reduce the environmental impact.
Concrete proposal for felodipine
Comparative assessment of environmental risk with the use of calcium antagonists amlodipine and felodipine in Sweden.
Amlodipine is estimated to be much less fat soluble (log P = 2.1) than felodipine (log P = 4.5). Experimental data (methodology partially unclear) suggests a slightly smaller difference (amlodipine log P = 3.04; felodipine 3.8 to 3.86). Although there are some uncertainties about the exact fat solubility of the substances, both chemical data and comparable data indicate that felodipine is more ecotoxic than amlodipine.
Amlodipine, recommended in the Wise list, is better from an environmental point of view than felodipine.
Author: The Pharmaceutical unit of Region Stockholm