Propofol

Detaljerad information

Fass miljöinformation

Fass miljöinformation för Diprivan (propofol) från AstraZeneca (hämtad 2011-05-24).

Fara

Persistens OECD guideline 301F: "The results showed that propofol is not biodegradable, with <5% biodegradation after 28 days. However, >91% removal of propofol from the aqueous phase was observed, which was noted at the time as being possibly due to adsorption to the solid phase.

ISO Guideline 11734: The results showed that propofol was not biodegradable under the anaerobic conditions of the test, although a degree of elimination was observed."

"The medicine is potentially persistent."

Bioackumulation: "Log P = 3.9 (at pH 8). BCF 28 D = 27 (at 2 μg/L) and 28 D = 26 (at 0.2 μg/L). [...] Bioconcentration factor (BCF) 28 D = 27 (at 2 µg/L). Bioconcentration factor (BCF) 28 D = 26 (at 0.2 µg/L) These values are well below the trigger value for PBT testing of 2000. Therefore the statement ‘No significant bioaccumulation potential’ is used."

Toxicitet: Finns data för 3 trofinivåer, lägst för kräftdjur (Daphnia magna) NOEC kronisk toxicitet 230 mikrog/L.

Risk

PEC/PNEC utgår från försäljningsdata i Sverige under år 2009. PEC/PNEC = 0,16 vilket ger risken låg.

"Chronic studies have been performed at two trophic levels, ie algae and Daphnia magna, the latter being the most sensitive of these species. This would give an assessment factor of 50. However, there is no acute data for the Daphnia magna or algae trophic levels, so no comparison to the fish acute data can be made to determine which is actually the most sensitive species Therefore, the PNEC_{surface water} will be based on the most sensitive fish species as a worst-case assumption; rainbow trout 96h LC₅₀ of 0.37 mg/L."

Rappporten Läkemedelsrester i Stockholms vattenmiljö

Propofol anges som lättnedbrytbart.